GSK-872 hydrochloride Datasheet DC Chemicals

Description	GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
Cat.No	DC46825
Name	GSK-872 hydrochloride

Chemical Properties

CAS	2703752-81-0
Formula	C19H18CLN3O2S2
MW	419.95
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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