HAIYPRH hydrochloride, a transferrin receptor-specific peptide, is chosen as the ligand to target the co-delivery system to the tumor cells expressing transferrin receptors. HAIYPRH-modified co-delivery system shows higher efficiency in cellular uptake and gene expression than unmodified co-delivery system in U87 MG cells, and accumulated in tumor more efficiently in vivo[1].
In Vitro
HAIYPRH hydrochloride (T7) is conjugated to liposomes for ischemic stroke targeting treatment of a novel neuroprotectant (HY-100456: ZL006)[2].
HAIYPRH hydrochloride is a heptapeptide that can be used to target gliomas[3].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Liu S, et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012;33(19):4907‐4916.
[2]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015;5:12651. Published 2015 Jul 29.
[3]. Ziyang Zhu, et al. Goat milk-derived exosomes Endowed with Radioactive and Targeting Properties: potential to provide PET/CT monitoring for exosomes-based drug delivery system in gliomas therapy. J Nucl Med May 1, 2020 vol. 61.
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