HGC652 Datasheet DC Chemicals

Description	HGC652 is a first-in-class molecular glue that selectively recruits the E3 ubiquitin ligase TRIM21 to form a ternary complex with NUP98, triggering targeted degradation of NUP155 and nuclear pore complex (NPC) proteins. This unique mechanism induces potent cytotoxicity across multiple cancer types, with activity correlating with cellular TRIM21 expression levels.
Cat.No	DC67394
Name	HGC652

Chemical Properties

CAS	3055558-98-7
Formula	C23H28FNO3S2
MW	449.60
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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