I-CBP112 hydrochloride Datasheet DC Chemicals

Description	I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
Cat.No	DC48140
Name	I-CBP112 hydrochloride

Chemical Properties

CAS	2147701-33-3
Formula	C27H37CLN2O5
MW	505.05
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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