IAJD34 is a monocomponent lipid nanoparticle (LNP) engineered for selective mRNA delivery to the lungs. Its design leverages a large hydrophobic structure and a pH-dependent surface charge (pKa 6.74), enabling preferential accumulation in the pulmonary compartment after intravenous injection. This property allows it to bypass traditional delivery barriers and achieve high-efficiency transfection in distal airways (beyond the 16th bronchial generation), a critical target region for treating lung diseases like acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD).
Cat.No
DC67292
Name
IAJD34
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Meshanni, J.A., Stevenson, E.R., Zhang, D. et al. Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers. Nat Commun 16, 1806 (2025). https://doi.org/10.1038/s41467-025-56448-y
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