IMA-1 Datasheet DC Chemicals

Description	IMA-1 is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.IMA-1 markedly blocked diet-induced NASH progression in both male mice and Cynomolgus macaque therapeutic models.The anti-NASH efficacy of IMA-1 was comparable to ACC inhibitor in both species.IMA-1 directly binds to a pocket in ALOX12 proximal to its ACC1-interacting surface instead of inhibiting ALOX12 lipoxygenase activity.IMA-1 treatment did not elicit hyperlipidemia, a known side effect of direct inhibition of ACC enzymatic activity, in both mice and macaques.
Cat.No	DC70506
Name	IMA-1

Chemical Properties

CAS	2315406-63-2
Formula	C27H27N3O10S2
MW	617.644
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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