INCB14943 Datasheet DC Chemicals
Description INCB14943, also known as INCB024360-analog, IDO5L and IDO-IN-2 with CAS#914471-09-3, is a potent and orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1) with potential immunomodulating and antineoplastic activities. INCB024360-analog is a potent (HeLa IC50=19 nM) competitive inhibitor of IDO. Testing of INCB024360-analog in mice demonstrated pharmacodynamic inhibition of IDO, as measured by decreased kynurenine levels (>50%) in plasma and dose dependent efficacy. ||Note: MedKoo CAT#206461, INCB024360 has CAS#1204669-58-8 (http://www.medkoo.com/products/6778)
Cat.No DC75459
Name INCB14943

Chemical Properties

CAS 914471-09-3
Formula C9H7CLFN5O2
MW 271.63
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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