Iu1-248 Datasheet DC Chemicals
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Cat.No DC71668
Name Iu1-248

Chemical Properties

CAS 2307472-03-1
Formula C20H23N3O2
MW 337.4155
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2307472-03-1
Product Name：4-{3-[(4-Hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile
Synonyms：4-{3-[(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile;4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile;Benzonitrile, 4-[3-[2-(4-hydroxy-1-piperidinyl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-;A8O;Benzonitrile, 4-a[3-a[2-a?4-ahydroxy-a?-apiperidinyl)aacetyl]a?a?,a?-adimethyl-a?H-apyrrol-a?-ayl]a?;IU1-248
EINEC:
Molecular Formula：C20H23N3O2
Molecular Weight：337.4155
Target:
In Vivo
In Vitro IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.
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