JBJ-04-125-02 R-isomer Datasheet DC Chemicals

Description	JBJ-04-125-02 is a mutant-selective EGFR allosteric inhibitor with potential anticancer activity. As a single agent, it can inhibit cell proliferation and EGFRL858R/T790M/C797S signaling in vitro and in vivo. The combination of osimertinib and JBJ-04-125-02 results in an increase in apoptosis, a more effective inhibition of cellular growth, and an increased efficacy in vitro and in vivo compared with either single agent alone.
Cat.No	DC75674
Name	JBJ-04-125-02 R-isomer

Chemical Properties

CAS	2060610-53-7
Formula	C29H26FN5O3S
MW	543.617
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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