JC-229 Datasheet DC Chemicals

Description	JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei, the causative parasite of African trypanosomiasis. JC-229 is highly toxic to T. brucei cells, while mildly toxic to human cells. JC-229 treatment mimics the effects of TbRPA1 depletion, including DNA replication inhibition and DNA damage accumulation. JC-229 inhibits the activity of TbRPA1, but not the human ortholog.
Cat.No	DC65616
Name	JC-229

Chemical Properties

CAS
Formula	C20H14CL4N2O3S
MW	504.200
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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