JDQ-443 Datasheet DC Chemicals
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Cat.No DC47210
Name JDQ-443

Chemical Properties

CAS 2653994-08-0
Formula C29H28CLN7O
MW 526.03
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2653994-08-0
Product Name：Opnurasib
Synonyms：2-Propen-1-one, 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-;JDQ-443;JDQ-443 (Synonyms: NVP-JDQ443);NVP-JDQ443;Opnurasib
EINEC:
Molecular Formula：C29H28CLN7O
Molecular Weight：526.03
Target: KRas G12C
In Vivo
In Vitro JDQ-443 (NVP-JDQ443) traps the GDP-bound inactive conformation of KRAS[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1.
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