JKE-1674 Datasheet DC Chemicals

Description	JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor. JKE-1674 kills cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors[1].
Cat.No	DC65475
Name	JKE-1674

Chemical Properties

CAS	2421119-60-8
Formula	C20H20CL2N4O4
MW	451.303202629089
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506.

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