JNJ16259685 Datasheet DC Chemicals

Description	JNJ16259685 is a potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). JNJ16259685 inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. JNJ16259685 is selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM).
Cat.No	DC75529
Name	JNJ16259685

Chemical Properties

CAS	409345-29-5
Formula	C20H23NO3
MW	325.408
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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