JWJ-01-378 Datasheet DC Chemicals

Description	JWJ-01-378 is a selective TRK PROTAC degrader. JWJ-01-378 efficiently degrades WT TRK and TPM3-TRKA fusion proteins and inhibits downstream pERK signaling, while showing limited efficacy against TRK inhibitor resistant mutants and ALK fusions. JWJ-01-378 potently suppresses cancer cell proliferation.
Cat.No	DC79378
Name	JWJ-01-378

Chemical Properties

CAS
Formula	C55H62F2N10O9
MW	1045.14
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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