Lintuzumab Datasheet DC Chemicals
Description Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR? and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice.
Cat.No A142
Name Lintuzumab

Chemical Properties

CAS 166089-32-3
Synonyms Immunoglobulin G1,anti-(human CD33 (antigen)) (human-mouse monoclonal HuM195 g1-chain), disulfide withhuman-mouse monoclonal HuM195 k-chain, dimer;HuM195;Lintuzumab;Immunoglobulin G1,anti-(human CD33 (antigen)) (human-mouse monoclonal HuM195 g1-chain), disulf...;Immunoglobulin G1,anti-(human CD33 (antigen)) (human-mouse monoclonal HuM195 g1-chain), disulfide withhuman-mouse monoclonal ;Immunoglobulin G1 anti-(human CD33 (antigen)) (human-mouse monoclonal HuM195 gamma1-chain), disulfide with human monoclonal HuM195 kappa-chain, dimer;Immunoglobulin G1, anti-(human CD33 (antigen)) (human-mouse monoclonal HuM195 gamma1-chain), disulfide with human-mouse monoclonal HuM195 kappa-chain, dimer;Lintuzumab [INN];Hum 195;Immunoglobulin G1, anti-(human cd33 (antigen)) (human-mouse monoclonal hum195 gamma1-chain), disulfide with human-mouse monoclonal hum195 kappa-chain, dimer;Lintuzumab [inn];Research Grade Lintuzumab (DHD37502)
pH value Corresponds to reference standard: PASS
Non-reduced CE-SDS >95%
SEC-HPLC >95%
Isoelectric Point Corresponds to reference standard
Bacterial Endotoxins Test
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity
Osmolality Corresponds to reference standard: PASS
Peptide mapping Corresponds to reference standard: PASS
N-terminal sequence Corresponds to reference standard: PASS

References

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