Lipid-168 Datasheet DC Chemicals

Description	Lipid-168, an ionizable lipid from Library A, features a diethylamino headgroup and optimized hydrophobic tail, enabling efficient mRNA delivery to bone marrow (BM) cells via protein corona-mediated targeting (e.g., albumin, fibronectin). It exhibits a pKa of ~6.5, facilitating endosomal escape, and achieves >90% mRNA encapsulation efficiency. LNPs formulated with Lipid-168 demonstrated 48.5% editing efficiency in BM cells after dual dosing in vivo, with reduced hepatic off-targeting through miR-122T incorporation. Cryo-EM confirmed uniform nanoparticle morphology (80-90 nm). Safety assessments showed transient cytokine spikes without sustained immunogenicity.
Cat.No	DC60683
Name	Lipid-168

Chemical Properties

CAS
Formula
MW
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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