Lipid A9 Datasheet DC Chemicals

Description	Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo. LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.
Cat.No	DC57100
Name	Lipid A9

Chemical Properties

CAS	2036272-50-9
Formula	C57H112N2O5
MW	905.51
Storage	-20

References

1. Buschmann, M.D., Carrasco, M.J., Alishetty, S., et al. Nanomaterial delivery systems for mRNA vaccines. Vaccines (Basel) 9(1), 65 (2021). 2. Holland, R., Lam, K., Jeng, S., et al. Silicon ether ionizable lipids enable potent mRNA lipid nanoparticles with rapid tissue clearance. ACS Nano 18(15), 10374-10387 (2024).

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