Chemical Properties
| CAS |
2180923-05-9 |
 |
| Formula |
C45H48CLN7O8S |
| MW |
882.422728538513 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：2180923-05-9
Product Name：Lisaftoclax
Synonyms：Bcl-2/Bcl-xl inhibitor 1;OSL3FEZ1IF;US10221174, Compound 6;BDBM361577;(S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin- 5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6- en-7-yl)methyl)piperazin-1-yl)benzamide;Benzamide, 4-(4-((6-(4-chlorophenyl)spiro(3.5)non-6-en-7-yl)methyl)-1-piperazinyl)-N-((4-(((2S)-1,4-dioxan-2-ylmethyl)amino)-3-nitrophenyl)sulfonyl)-2-(1H-pyrrolo(2,;Lisaftoclax
EINEC:
Molecular Formula：C45H48CLN7O8S
Molecular Weight：882.422728538513 |
| Target: |
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| In Vivo |
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| In Vitro |
Lisaftoclax (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells. |
| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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