LMP744 free base Datasheet DC Chemicals

Description	LMP744, also known as Mj-III-65 and NSC-706744, is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts.
Cat.No	DC74668
Name	LMP744 free base

Chemical Properties

CAS	308246-52-8
Formula	C24H24N2O7
MW	452.463
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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