MF59 represents a highly efficacious oil-in-water emulsion adjuvant, renowned for its commendable safety profile and its capacity to mitigate immunosenescence—the age-associated decline in immune function—particularly in the elderly population. Primarily engineered for incorporation into influenza vaccines, MF59-adjuvanted formulations have demonstrated superior efficacy in eliciting robust immune responses among older adults when juxtaposed with conventional inactivated influenza vaccines. The adjuvant's formulation is characterized by squalene droplets, meticulously stabilized with minimal quantities of the surfactants Tween 80 and Span 85. This unique composition not only augments the immunogenic potential of influenza antigens but also broadens the spectrum of the immune response. It achieves this by enhancing cross-reactivity against viral strains that are not explicitly represented within the vaccine, thereby offering a more comprehensive protective umbrella against influenza.
Cat.No
DC67249
Name
MF59
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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