MSU 38225 (MSU-38225) is a novel small molecule that inhibit the Nrf2 pathway, potentially inhibiting Nrf2 transcriptional activity and cancer cell growth;
MSU38225 downregulates Nrf2 transcriptional activity and decreases the expression of Nrf2 downstream targets, including NQO1, GCLC, GCLM, AKR1C2, and UGT1A6.
MSU38225 strikingly decreases the protein level of Nrf2, which can be blocked by the proteasome inhibitor MG132.
Ubiquitination of Nrf2 is enhanced following treatment with MSU38225.
By inhibiting production of antioxidants, MSU38225 increases the level of reactive oxygen species (ROS) when cells are stimulated with tert-butyl hydroperoxide (tBHP).
MSU38225 also inhibits the growth of human lung cancer cells in both two-dimensional cell culture and soft agar.
Cat.No
DC70623
Name
MSU38225
Chemical Properties
CAS
1629160-83-3
Formula
C21H19N3
MW
313.404
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
1. Di Zhang, et al. Mol Cancer Ther. 2021 Sep;20(9):1692-1701
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