NH-23-C2 Datasheet DC Chemicals

Description	NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S).HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM).NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
Cat.No	DC70648
Name	NH-23-C2

Chemical Properties

CAS
Formula	C43H51N5O13
MW	845.903
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Marcin Poreba, et al. Cell Death Differ. 2019 Dec;26(12):2695-2709.

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