Onvansertib free base Datasheet DC Chemicals

Description	Onvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Onvansertib selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.
Cat.No	DC75279
Name	Onvansertib free base

Chemical Properties

CAS	1034616-18-6
Formula	C24H27F3N8O3
MW	532.528
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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