2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：864084-88-8 Product Name：Opiorphin trifluoroacetate salt Synonyms：L-Arginine,L-glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-;OPIORPHIN;H-Gln-Arg-Phe-Ser-Arg-OH;human opiorphin;L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine;BDBM50382499;Q416529;(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]pentanoic acid;SCHEMBL20257129;GTPL11538;864084-88-8;HY-W345510;CS-0456478;MFCD09752700;D93123;DTXSID901027119;CHEMBL2022225;AKOS037646654;Gln-Arg-Phe-Ser-Arg;QRFSR peptide;CHEBI:177467;AS-70071;Opiorphin;Opiorphin trifluoroacetate salt EINECS: Molecular Formula：C29H48N12O8 Molecular Weight：692.7670
Target:
In Vivo
Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg)[1]. Animal Model: Male Kunming mice[1] Dosage: 1.25, 2.5, 5, 10 μg/kg Administration: Intracerebroventrical injection; post-drug latency measurements were performed at 5, 10, 20, 30, 40, 50 and 60 min Result: Had the percentage change of tail withdrawal latency (TWL) at 10 min after i.c.v. administration of 1.25-10 mg/kg was 28.90%, 44.37%, 56.43% and 91.899.79%, respectively
In Vitro
Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin[1]. Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM.
Kinase Assay
Cell Assay
Animal Administration
References
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