2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：220643-77-6 Product Name： Synonyms： EINECS: Molecular Formula：C25H28ClIN4O2 Molecular Weight：578.87
Target:
5-HT1A Receptor
In Vivo
p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2]. Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2] Dosage: 0.5, 1.5, 4.5 mg/kg Administration: i.p. Result: Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
In Vitro
p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.
[2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
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