p38 MAP Kinase Inhibitor IV Datasheet DC Chemicals
Description p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
Cat.No DC33255
Name p38 MAP Kinase Inhibitor IV

Chemical Properties

CAS 1638-41-1
Formula C12H4CL6O4S
MW 456.92
Storage

References

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