Pexidartinib HCl Datasheet DC Chemicals
Description Pexidartinib, also known as PLX-3397, is a CSF1R inhibitor with IC50 of 20 nM in development by Plexxikon for the treatment of tenosynovial giant cell tumors. It is in a phase 3 clinical trial for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS). Pexidartinib hydrochloride exposure induces developmental toxicity and immunotoxicity in zebrafish embryos via activation of Wnt signaling.
Cat.No DC75855
Name Pexidartinib HCl

Chemical Properties

CAS 2040295-03-0
Formula C20H16CL2F3N5
MW 454.28
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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