PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. Western Blot Analysis[1] Cell Line: RH4 and SCMC cells Concentration: 3 μΜ Incubation Time: 24 hours Result: Apoptosis increased in RH4 and SCMC cells.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1
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