| Description |
Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.,5-HT2B [1](Cell-free assay)
5-HT2A [1](Cell-free assay)
Histamine H1 Receptor [1](Cell-free assay)
Muscarinic M2 [1](Cell-free assay)
Muscarinic M1 [1](Cell-free assay)
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10.44(pKi)
10.22(pKi)
10.14(pKi)
9.38(pKi)
8.61(pKi) |
| Cat.No |
DC44781 |
| Name |
Pimethixene maleate |
Chemical Properties
| CAS |
13187-06-9 |
|
| Formula |
C23H23NO4S |
| MW |
409.498025178909 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
References
|
[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. |
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