PLX-3618 Datasheet DC Chemicals

Description	PLX-3618 is a targeted molecular glue that induces the degradation of BRD4, a key epigenetic regulator implicated in cancer. It achieves potent BRD4 degradation (DC50 = 12.2 nM) by recruiting the E3 ubiquitin ligase adapter DCAF11, which tags BRD4 with polyubiquitin chains for proteasome-mediated destruction.
Cat.No	DC67339
Name	PLX-3618

Chemical Properties

CAS	2851986-76-8
Formula	C32H27N9O2S
MW	601.680883646011
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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