RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain.
Cat.No
DC70734
Name
RET agonist BT44
Chemical Properties
CAS
924759-42-2
Formula
C28H27F4N3O4S
MW
577.595
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
1. Viisanen H, et al. Mol Pain. 2020 Jan-Dec;16:1744806920950866. 2. Renko JM, et al. J Parkinsons Dis. 2021;11(3):1023-1046.
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