Rupitasertib free base Datasheet DC Chemicals

Description	Rupitasertib, also known as M2698, MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K).
Cat.No	DC75465
Name	Rupitasertib free base

Chemical Properties

CAS	1379545-95-5
Formula	C21H19CLF3N5O
MW	449.862
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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