Sacituzumab Datasheet DC Chemicals
Description Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab is used for the synthesis of antibody-drug conjugates (ADC) drugs. Antibody-drug conjugates with sacituzumab (sacituzumab govitecan) (HY-132254) targeting TROP-2 have been approved for the field of triple-negative breast cancer.
Cat.No A620
Name Sacituzumab

Chemical Properties

CAS 1796566-95-4
Synonyms Sacituzumab;CYSTEINYL CL2A-SN-38;CYSTEINYL CL2A-SN-38;M9BYU8XDQ6;M9BYU8XDQ6;sacituzumab-govitecan;sacituzumab-govitecan;DTXSID401335985;DTXSID401335985;DTXSID401335985;hRS7-SN38;hRS7-SN38;hRS7-SN38;hRS7-SN38;IMMU 132;IMMU 132;IMMU 132;IMMU 132;SN-38 CYSTEINYL CONJUGATE;SN-38 CYSTEINYL CONJUGATE;SN-38 CYSTEINYL CONJUGATE;SN-38 CYSTEINYL CONJUGATE;IMMU-132;IMMU-132;IMMU-132;IMMU-132;Sacituzumab govitecan [USAN];Sacituzumab govitecan [USAN];Sacituzumab govitecan [USAN];Sacituzumab govitecan [USAN];EX-A4354;EX-A4354;EX-A4354;EX-A4354;DA64T2C2IO;DA64T2C2IO;DA64T2C2IO;DA64T2C2IO;1535963-91-7;1535963-91-7;1535963-91-7;1535963-91-7;DA-77702;DA-77702;DA-77702;DA-77702;GOVITECAN CYSTEINYL CONJUGATE;GOVITECAN CYSTEINYL CONJUGATE;GOVITECAN CYSTEINYL CONJUGATE;GOVITECAN CYSTEINYL CONJUGATE;F82944;F82944;F82944;F82944;Sacituzumab govitecan;Sacituzumab govitecan;Sacituzumab govitecan;Sacituzumab govitecan;hRS 7SN38;hRS 7SN38;hRS 7SN38;hRS 7SN38;Satralizumab linker;Satralizumab linker;Satralizumab linker;Satralizumab linker;1796566-95-4;1796566-95-4;1796566-95-4;1796566-95-4;UNII-M9BYU8XDQ6;UNII-M9BYU8XDQ6;UNII-M9BYU8XDQ6;UNII-M9BYU8XDQ6;1491917-83-9;1491917-83-9;1491917-83-9;1491917-83-9
pH value Corresponds to reference standard: PASS
Non-reduced CE-SDS >95%
SEC-HPLC >95%
Isoelectric Point Corresponds to reference standard
Bacterial Endotoxins Test
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity
Osmolality Corresponds to reference standard: PASS
Peptide mapping Corresponds to reference standard: PASS
N-terminal sequence Corresponds to reference standard: PASS

References

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