2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：2922283-37-0 Product Name：SG-094 Synonyms： EINECS: Molecular Formula：C30H29NO3 Molecular Weight：451.56
Target:
TPC2[1]
In Vivo
In Vitro
SG-094 (72 hours) shows antiproliferative effects against RIL175 cells, with an IC50 of 3.7 μM[1].
SG-094 (10 μM) blocks PI(3,5)P2-elicited TPC2 currents on isolated endolysosomes from HEK293 cells expressing TPC2-EGFP[1].
SG-094 (10 μM; pretreated for 1 h) significantly reduces VEGF-induced phosphorylation of eNOS, JNK, MAPK, and AKT without decreasing their total protein levels in HUVECs[1].
SG-094 (1-5 μM; pretreated for 1 h) increases OCR/ECAR ratios of RIL175 WT cells after glucose starvation[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27.
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