SGC-SMARCA-BRDVIII Datasheet DC Chemicals
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Cat.No DC48075
Name SGC-SMARCA-BRDVIII

Chemical Properties

CAS 1997319-84-2
Formula C19H25N5O3
MW 371.43
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1997319-84-2
Product Name：SGC-SMARCA-BRDVIII
Synonyms：SGC-SMARCA-BRDVIII; SGCSMARCABRDVIII; SGC SMARCA BRDVIII;
EINECS:
Molecular Formula：C19H25N5O3
Molecular Weight：371.43
Target: Kd: 35 nM (SMARCA2), 36 nM (SMARCA4), 13 nM (PB1(5))[1]
In Vivo
In Vitro SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [2]. Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338.
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