SIAIS164018 Datasheet DC Chemicals

Description	SIAIS164018 is a PROTAC-based ALK and EGFR degrader, which is designed from Brigatinib, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib.
Cat.No	DC71634
Name	SIAIS164018

Chemical Properties

CAS	2353492-68-7
Formula	C43H48CLN10O7P
MW	883.33
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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