Sintilimab Datasheet DC Chemicals

Description	Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer.
Cat.No	A645
Name	Sintilimab

Chemical Properties

CAS	2072873-06-2
Synonyms	Tyvyt;IBI 308 antibody;IBI 308;Centilimab;Sintilimab;Sintilimab (anti-PD-1);Sintilimab (anti-PD-1);Research Grade Sintilimab(DHH02207);Research Grade Sintilimab(DHH02207)
pH value	Corresponds to reference standard: PASS
Non-reduced CE-SDS	>95%
SEC-HPLC	>95%
Isoelectric Point	Corresponds to reference standard
Bacterial Endotoxins Test
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity
Osmolality	Corresponds to reference standard: PASS
Peptide mapping	Corresponds to reference standard: PASS
N-terminal sequence	Corresponds to reference standard: PASS

References

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