SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).SM360320 inhibited HCV replication in Huh-7 cells in a dose-dependent manner in the Huh-7 replicon system, reduced HCV mRNA and protein levels in isolated Huh-7 hepatocytes.SM360320 induced in vivo secretion of interferon alpha (IFNalpha) and exerted a significant antitumor effect in CEA.Tg mice challenged with a syngenic tumor cell line expressing CEA.SM360320 exerts significant antitumor effects and can act in association with DNA-EP for CEA-positive colon cancer and HER2-positive mammary carcinoma.Repeated low dose administration of SM360320 induced hyporesponsiveness or tolerance to TLR2, -7, and -9 activators and limited the course of neural inflammation in an experimental allergic encephalomyelitis model.
Cat.No
DC70786
Name
SM360320
Chemical Properties
CAS
226907-52-4
Formula
315.333
MW
C15H17N5O3
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
