CAS NO.：50440-30-7 Product Name：Benzamide,4-[(6-nitro-4-quinolinyl)amino]-N-[4-(4-pyridinylamino)phenyl]- Synonyms：Benzamide,4-[(6-nitro-4-quinolinyl)amino]-N-[4-(4-pyridinylamino)phenyl]-;4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide;HMS2860I06 EINEC: Molecular Formula：C27H20N6O3 Molecular Weight：476.4861
Target:
In Vivo
T3Inh-1 (25 or 50 mg/kg; i.p.) blocks ppGalNAc-T3-mediated glycan-masking of FGF23 thereby increasing its cleavage[1].
In Vitro
T3Inh-1 (5 µM; 24-48 hours; 5 µM; MDA-MB231 cells) is strikingly effective, inhibiting migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation[1].
T3Inh-1 exhibits no toxicity and did not affect HEK cell proliferation[1].
T3Inh-1 (HEK cells; 6 hours)increases cleavage of FGF23[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Song L, et al. Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels. Elife. 2017;6:e24051. Published 2017 Mar 31.
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