Description
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research.
Cat.No
A1002
Name
Toralizumab
Chemical Properties
CAS
252662-47-8
Synonyms
Immunoglobulin G1,anti-(human CD40 ligand) (human-mouse monoclonal IDEC-131 g1-chain), disulfide withhuman-mouse monoclonal IDEC-131 k-chain, dimer;Immunoglobulin G1,anti-(human CD40 ligand) (human-mouse monoclonal IDEC-131 g1-chain), disulfide withhuman-mouse monoclonal I;anti-CD 154;anti-CD 154 mAb;anti-gp39;E6040;Eisai;gp39 antibody;IDEC;IDEC 131;Toralizumab;ANTI-TRAP;ANTI-HUMAN CD154;ANTI-HUMAN SCD40 LIGAND;ANTI-HUMAN SOLUBLE CD40 LIGAND;ANTI-HUMAN T-BAM;ANTI-HUMAN TRAP;ANTI-HUMAN TNFSF5
pH value
Corresponds to reference standard: PASS
Non-reduced CE-SDS
>95%
SEC-HPLC
>95%
Isoelectric Point
Corresponds to reference standard
Bacterial Endotoxins Test
Residual Proteins of Host Cell
Exogenous Residual DNA
Residual protein A
Biological Activity
Osmolality
Corresponds to reference standard: PASS
Peptide mapping
Corresponds to reference standard: PASS
N-terminal sequence
Corresponds to reference standard: PASS
References
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