TTC-352 Datasheet DC Chemicals

Description	TTC352 is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.TTC 352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ERα's ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ERα-induced unfolded protein response (UPR) and apoptosis.TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ERα-mediated UPR and apoptosis.
Cat.No	DC70851
Name	TTC-352

Chemical Properties

CAS	1607819-68-0
Formula	C20H13FO3S
MW	352.378827810287
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Balkees Abderrahman, et al. Mol Cancer Ther. 2021 Jan;20(1):11-25.

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