U-101 Datasheet DC Chemicals

Description	U-101 is an ionizable lipid for mRNA delivery. U-101-LNP/IL-2F mRNA formulation demonstrats effective antitumor activity and safety.LNPs containing lipid U-101 and encapsulating mRNA encoding a fusion protein composed of IL-2, a linker, and CD25 inhibit tumor growth in an MC-38 mouse xenograft model.
Cat.No	DC60575
Name	U-101

Chemical Properties

CAS
Formula	C51H102N2O6
MW	839.4
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

Jiang, Y., Zhang, Y., Liu, C., et al. Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy. J. Control. Release 368, 663-675 (2024).

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