UHRF1 PHD inhibitor MLD4 Datasheet DC Chemicals

Description	UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
Cat.No	DC70865
Name	UHRF1 PHD inhibitor MLD4

Chemical Properties

CAS	922067-76-3
Formula	C22H32N4O4
MW	416.522
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.

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