| Description |
Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. |
| Cat.No |
A873 |
| Name |
Ulocuplumab |
Chemical Properties
| CAS |
1375830-34-4 |
|
| Synonyms |
BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody |
| pH value |
Corresponds to reference standard: PASS |
| Non-reduced CE-SDS |
>95% |
| SEC-HPLC |
>95% |
| Isoelectric Point |
Corresponds to reference standard |
| Bacterial Endotoxins Test |
|
| Residual Proteins of Host Cell |
|
| Exogenous Residual DNA |
|
| Residual protein A |
|
| Biological Activity |
|
| Osmolality |
Corresponds to reference standard: PASS |
| Peptide mapping |
Corresponds to reference standard: PASS |
| N-terminal sequence |
Corresponds to reference standard: PASS |
References
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