VB124 (30 mg/ kg; twice per day for 180 days) has no effect on body, heart, liver, or lung weight of mice, suggesting no overt toxicities[1]. VB124 (30 mg/kg; p.o.; daily for 28 days) attenuates isoproterenol-induced cardiac hypertrophy in mice[1]. Animal Model: 12 weeks old C57BL/6 mice[1] Dosage: 30mg/kg Administration: Oral gavage; daily for 28 days (dissolved in 0.5% methylcellulose and 0.1% Tween-20) Result: Prevented cardiac hypertrophy in mice
In Vitro
VB124 （10 μM） inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50%[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-231 cells Concentration: 10 μM Incubation Time: Result: Inhibited the cell proliferation of MDA-MB-231 cells (proliferation rate：＜50%).
Kinase Assay
Cell Assay
Animal Administration
References
[1]. [1] Cluntun AA, et.al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2021 Mar 2;33(3):629-648.e10.
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
