VVD-133214 Datasheet DC Chemicals

Description	VVD-133214 is a covalent allosteric inhibitor of WRN helicase with potent cellular TE50 in both human and mouse WRN helicase DNA unwinding assays. VVD-133214 potently inhibits cell growth in MSI-H HCT-116 cells with GI50 of 0.066 μM but in neither MSS SW480 nor HCT-116 WRN C727A mutant cells.
Cat.No	DC60588
Name	VVD-133214

Chemical Properties

CAS
Formula
MW
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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