AP-14145 HCl is a KCa2 (small conductance Ca2±activated potassium) channel negative allosteric modulator. AP-14145 HCl triples the EC50 of Ca2+ on KCa2.3 channelsand prolongs atrial effective refractory period (AERP). It also reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.