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COA of MAGL Inhibitor Compound 23

Description:

MAGL Inhibitor Compound 23 is an inhibitor of monoacylglycerol lipase (MAGL). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12. MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells but not MRC5 cells. It increases the levels of 2-arachidonoyl glycerol (2-AG) in mouse brain and plasma when administered at a dose of 50 mg/kg.

Chemical Information

Catalog Novel inhibitors
Molecular Weight (MW) 369.44
Molecular Formula C22H24FNO3

Handling:

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.