Mezigdomide is a cereblon E3 ubiquitin ligase modulator with immunomodulatory and antineoplastic properties. By specifically binding to cereblon (CRBN), it alters the activity of the ubiquitin E3 ligase complex, leading to the ubiquitination and subsequent proteasome-mediated degradation of specific transcription factors, including those that act as transcriptional repressors in T cells. This process modulates immune system activity, such as T lymphocyte activation, and suppresses the function of proteins critical for the proliferation of certain cancer cells.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.