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COA of JC-1
Description:
JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | >98% |
| CAS | 3520-43-2 |
| Molecular Weight (MW) | 652.2235 |
| Molecular Formula | C25H27Cl4IN4 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Reference:
1. Abdalah, R., Wei, L., Francis, K., et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neuroscience Letters 405, 68-73 (2006).
2. Petit, P.X., Lecoeur, H., Zorn, E., et al. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. Journal of Cell Biology 130(1), 157-167 (1995).
3. Salvioli, S., Ardizzoni, A., Franceschi, C., et al. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess Δψ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis. FEBS Letters 411, 77-82 (1997).